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KMID : 0606920110190030324
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.324 ~ p.330
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Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica
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Ko Hyun-Jeong
Jin Jeong-Ho
Kwon Oh-Song
Kim Jong-Taek
Son Kun-Ho
Kim Hyun-Pyo
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Abstract
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Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of infl ammatory disorders, especially respiratory infl ammation, in Chinese medicine. Previously, phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-infl ammatory activity in vitro and in vivo. In this study, the effects of BL on lung infl ammation including bronchitis were examined in vitro and in vivo. BL (10-100 ?g/ml) inhibited nitric oxide (NO) production of lipopolysaccharide (LPS)-treated alveolar macrophages, MH-S cells, primarily by down-regulating inducible NO synthase. BL also inhibited production of the proinfl ammatory cytokines, TNF-α and IL-6. Against an animal model of pleural cavity infl ammation, BL (200-400 mg/kg) signifi cantly inhibited 5 h and 24 h carrageenan-induced pleurisy in rats when administered orally. Additionally, BL inhibited experimental bronchitis induced by intratracheal instillation of LPS to rats. Taken together, these results indicate that BL may be effective for the treatment of human lung infl ammation as well as bronchitis.
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KEYWORD
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Broussonetia papyrifera, Lonicera japonica, Lung infl ammation, Bronchitis
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